|Aspergilloma and Invasive Aspergillus|
• Aspergillus spores are widely disseminated in nature.
• Inhalation leads to disease.
• Organisms will proliferate in a pre-existing cavity in a immunocompetent host.
• Organisms will invade in the immunodeficient host.
• Patients who have
bronchiectasis secondary to obstruction, cystic fibrosis, sequestration etc.
• Patients who have tuberculosis.
• Patients who have abscesses.
• Immunocomporomsied individuals.
• Relatively asymptomatic patients with recurrent hemoptysis
• Or desperately ill immunosupressed patients.
|General Gross Description|
• Preexisting pulmonary cavity (old abscess, infarct etc) filled with
• Patients with invasive aspergillus will have multiple, hemorrhagic, firm nodules which may be centered around blood vessels.
|General Micro Description|
• Cavity often lined by squamous epithelium with profound cytologic atypia
which may be confused with squamous carcinoma
• Septate hyphae with branching at an acute angle
• Fruiting bodies may be seen
• In imunocompromised patients hyphae are seen invading bessel walls surrounded by necrosis and hemorrhage.
• Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th edition. Philadelphia, W.B. Saunders, 1994, pp. 353-4.