Granular Cell Tumor
Granular Cell Tumor
8; The large opened bronchus contains a nodule which is tan and soft, protruding into the lumen. € The black nodules distal to the neoplasm are carbon laden hilar lymph nodes. € The pulmonary parenchyma appears quite darkly congested.


(Image Contrib. by:UCHC)(Description by: Melinda Sanders,M.D.)
T28000E94710
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Endobronchial Neoplasms
Etiology

• Unknown.


Pathogenesis

• Carcinoids exhibit Kulchitsky cell differentation

• Salivary gland type neoplasms presumably arise from bronchial glands


Epidemiology

• Extremely uncommon.

• More frequent in young patients <40 years
.

• Unrelated to cigarette smoking


Clinical

• Cough with hemoptysis

• Systemic symptoms of distal pneumonia including fever, malaise, sweats etc

• Low grade neoplasms may metastasize to adjacent nodes

• For more information on prognosis and treatment, consult the NCI web site.
Visit National Cancer Institute for Current Treatment


General Gross Description

• Polypoid tan mass protruding into the lumen of a major bronchus

• Distal obstructive pneumonia may be profound with dilated mucous filled airways and consolidated firm parenchyma


General Micro Description

• >90% of these neoplasms are carcinoid tumors

• Remainder include low grade salivary gland malignancies such as adenoid cystic carcinoma and mucoepidermoid carcinoma

• Microscopic findings are identical to same neoplasms at other body sites


Reference

• Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th edition. Philadelphia, W.B. Saunders, 1994, pp. 726-727.


• Current literature from PubMed at National Library of Medicine


Synopsis by: Melinda Sanders M.D., UCHC
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