|
| Endobronchial Neoplasms |
| Etiology |
• Unknown. |
| Pathogenesis |
• Carcinoids exhibit
Kulchitsky cell differentation • Salivary gland type neoplasms presumably arise from bronchial glands |
| Epidemiology |
• Extremely uncommon. • More frequent in young patients <40 years • Unrelated to cigarette smoking |
| Clinical |
• Cough with hemoptysis • Systemic symptoms of distal pneumonia including fever, malaise, sweats
etc • Low grade neoplasms may metastasize to adjacent nodes • For more information on prognosis and treatment, consult the NCI web site. |
| General Gross Description |
• Polypoid tan mass protruding into the lumen of a major bronchus • Distal obstructive pneumonia may be profound with dilated mucous filled
airways and consolidated firm parenchyma |
| General Micro Description |
• >90% of these neoplasms are carcinoid tumors • Remainder include low grade salivary gland malignancies such as adenoid
cystic carcinoma and mucoepidermoid carcinoma • Microscopic findings are identical to same neoplasms at other body
sites |
| Reference |
• Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th edition. Philadelphia, W.B. Saunders, 1994, pp. 726-727.
|