• This is the lung distal to an obstructing intrabronchial neoplasm.
• The arrows point to bronchi distended by inspissated mucus extending out to the pleural surface.
• Although it is not visible, the surrounding lung was not aerated by palpation.
• Variety of aspirated organisms.
• Organism dependent on whether community acquired in previously healthy
patient (more likely Streptococcus) or
• Community acquired in patient with depressed pulmonary defenses such as a
patient with chronic bronchitis (more likely Klebsiella or Pseudomonas spps)
• Hospital acquired
• Aspiration of organisms results in inflammation and necrosis of
• Tends to scar if alveolar septae are destroyed
• Common in hospitalized patients and
contributes to the cause of death in moribund patients
• Most common community acquired pneumonia as well
• Clinical course dependent on underlying disease processes
• Patients present with fever, cough and purulent sputum
|General Gross Description|
• Patchy distribution particularly around small airways
• Nodular, elevated, firm, airless regions
• Range from red to gray depending on age of the lesion
• Can become confluent to mimic lobar pneumonia
|General Micro Description|
• Bronchocentric lesions
• Neutrophils fill airway and surrounding alveoli
• Parenchymal destruction depends on organism
• Uninvolved parenchyma may contain acellular pink edema
• Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th edition. Philadelphia, W.B. Saunders, 1994, pp. 694-698.